Human placental extracts (HPE) have been widely used in various diseases for a long time but criticized for the lack of clear evidence for clinical effectiveness and safety, which has caused controversies in the society. 

This study was performed

1) to review the results of domestic and foreign studies through the systematic reviews and, based on these results, to provide recent evidences for clinical effectiveness and safety of HPE

2) to understand the actual state of using human placenta injection (HPI) and social recognition for HPI through the survey, and then to provide accurate information to medical staffs, patients, and interested parties all related to the use of HPI.